What is Zyban® (bupropion)?

What is Zyban® (bupropion)?

Zyban® is the brand name for the non-nicotine stop smoking medication, bupropion, which can help with feelings of nicotine withdrawal such as cravings, irritability and difficulty concentrating. Zyban comes in tablets. In clinical trials, Zyban has been shown to increase quit rates.

How does Zyban work?

Zyban works appears to affect the area of the brain associated with reward, reducing cravings and feelings of withdrawal such as difficulty concentrating, frustration, restlessness and anxiety. It may also make smoking seem less satisfying.

Do I need a prescription for Zyban?

You will need a prescription from your doctor who will tell you if the medication is right for you. Initially, you will be prescribed a two-week pack of Zyban. You will need to go back to your doctor within two weeks for a review before you can be prescribed the rest of your Zyban tablets.

Who should use Zyban?

It’s important for you to discuss your individual situation with your doctor to decide if Zyban is right for you. Tell your doctor if you are on any medicines, have any medical conditions (including mental health conditions) or allergies, or if you are pregnant or breastfeeding. Zyban is not recommended for anyone under the age of 18.

Where can I buy Zyban?

Your prescription can be filled by your local pharmacist.

How much does Zyban cost?

You can get Zyban tablets at a cheaper price through the Pharmaceutical Benefits Scheme (PBS) if you have a Medicare card. There is a further discount available if you have a concession card. For prices, visit the PBS website at and type ‘Bupropion’ into the search bar.

How do I use Zyban?

Follow your doctor’s instructions regarding when and how often to take your Zyban tablets.

While you are taking Zyban, try to work on your stress management and strategies for beating the habit.

Getting support from an expert such as a Quitline counsellor can also be helpful – call 13 78 48.

Talk to your doctor about how long to take Zyban.

Can I try Zyban again?

It’s best to speak to your doctor or pharmacist about which stop smoking medication will suit you best when you’re ready to try quitting again.

How well does Zyban work?

Zyban helps many people to quit smoking, but may not work for everyone. Research has found that Zyban can more than double the chance of successfully quitting if combined with support like free Quitline counselling – 13 7848.  Quitline counsellors can give you tips and strategies for dealing with triggers and cues to smoke, while the medication helps to manage feelings of nicotine withdrawal and cravings.

Does Zyban have side effects?

As with all medicines, side effects can occur. Talk to your health professional about possible side effects. The most common side effects are headache, difficulty sleeping, dry mouth, dizziness, anxiety and nausea/vomiting. An uncommon, but serious side effect is seizures. A small number of people can have fever, joint and muscle pain with skin rash.

More information about side effects is available on the NPS MedicineWise website.

Some people may have mood or behaviour changes when taking Zyban. It’s important to let family members and close friends know that you are taking Zyban. Ask them to look out for any unusual changes in your behaviour or mood.

If you feel unwell or notice any changes in your mood or behaviour while taking Zyban, tell your doctor or pharmacist as soon as possible.

If I don’t succeed in quitting smoking using Zyban, can I try Champix (varenicline)?Ask your doctor if Champix is suitable for you. If so, you will need to obtain a prescription from your doctor for Champix.

Please note, this information is not intended to replace consumer medicines information or health professional advice. If you would like to provide feedback on this website content, please contact

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